Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Ping-Chung Kuo; Shih-Huang Tai; Ching-Che Hung; Tsong-Long Hwang; Liang-Mou Kuo; Sio Hong Lam; Kun-Ching Cheng; Daih-Huang Kuo; Hsin-Yi Hung; Tian-Shung Wu

doi:10.1016/j.bioorg.2020.104562

Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Bioorg Chem. 2021 Mar:108:104562. doi: 10.1016/j.bioorg.2020.104562. Epub 2020 Dec 16.

Authors

Affiliations

¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
² Departments of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School, Tainan 701, Taiwan.
³ Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
⁴ Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Industry of Human Ecology, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
⁵ Department of General Surgery, Chang Gung Memorial Hospital at Chia-Yi, 613, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
⁶ Taiwan Sugar Research Institute, Tainan 70176, Taiwan.
⁷ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan.
⁸ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address: z10308005@email.ncku.edu.tw.
⁹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.

PMID: 33358389
DOI: 10.1016/j.bioorg.2020.104562

Abstract

Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC₅₀ values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

Keywords: Antiinflammatory; Fomitopsidaceae; Fomitopsis pinicola; Triterpenoid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Coriolaceae / chemistry*
Dose-Response Relationship, Drug
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Fruiting Bodies, Fungal / chemistry*
Humans
Molecular Structure
Neutrophils / drug effects
Neutrophils / metabolism
Pancreatic Elastase / antagonists & inhibitors*
Pancreatic Elastase / metabolism
Structure-Activity Relationship
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Anti-Inflammatory Agents
Enzyme Inhibitors
Triterpenes
Pancreatic Elastase

Supplementary concepts

Fomitopsis pinicola