Abstract
Regular exercise reduces the risk of cancer. One potential mechanism for this efficacy is improved antitumor immunity. This is an important issue because evading immune destruction is a hallmark of cancer and immunotherapy is reshaping cancer treatment. Here we review recent developments reported by Wennerberg et al., Garritson et al., Martín-Ruiz et al., and Rundqvist et al. on the effects of exercise on anticancer immune cell effectors.
Keywords:
CD8+ cells; NK cells; lymphocytes; physical activity.
Copyright © 2021 Elsevier Inc. All rights reserved.
MeSH terms
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Combined Modality Therapy / methods
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Exercise / physiology
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Exercise Therapy / methods*
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Gene Expression Regulation / immunology
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Holistic Health
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Humans
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Immune Checkpoint Inhibitors / pharmacology*
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Immune Checkpoint Inhibitors / therapeutic use
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Immunologic Surveillance / drug effects
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Immunologic Surveillance / genetics*
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism
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Lymphocytes, Tumor-Infiltrating / drug effects
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Lymphocytes, Tumor-Infiltrating / immunology
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NK Cell Lectin-Like Receptor Subfamily K / metabolism
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Natural Cytotoxicity Triggering Receptor 1 / metabolism
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Neoplasms / immunology
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Neoplasms / therapy*
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T-Lymphocytes, Cytotoxic / immunology
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T-Lymphocytes, Regulatory / immunology
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Tumor Escape / drug effects
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / immunology
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Tumor-Associated Macrophages / immunology
Substances
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Immune Checkpoint Inhibitors
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KLRK1 protein, human
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NCR1 protein, human
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NK Cell Lectin-Like Receptor Subfamily K
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Natural Cytotoxicity Triggering Receptor 1