A systematic review of multifocal and multicentric glioblastoma

Yao Li; Zuo-Xin Zhang; Guo-Hao Huang; Yan Xiang; Lin Yang; Yu-Chun Pei; Wei Yang; Sheng-Qing Lv

doi:10.1016/j.jocn.2020.11.025

A systematic review of multifocal and multicentric glioblastoma

J Clin Neurosci. 2021 Jan:83:71-76. doi: 10.1016/j.jocn.2020.11.025. Epub 2021 Jan 7.

Authors

Yao Li¹, Zuo-Xin Zhang¹, Guo-Hao Huang¹, Yan Xiang¹, Lin Yang¹, Yu-Chun Pei¹, Wei Yang¹, Sheng-Qing Lv²

Affiliations

¹ Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China.
² Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China. Electronic address: lvsq0518@hotmail.com.

PMID: 33358091
DOI: 10.1016/j.jocn.2020.11.025

Abstract

Multiple glioblastoma multiforme (GBM) is classified as multifocal and multicentric GBM according to whether there is communication between the lesions. Multiple GBM is more genetically heterogeneous, aggressive and resistant to chemoradiotherapy than unifocal GBM, and has a worse prognosis. There is no international consensus on the treatment of multiple GBM. This review discusses some paradigms of multiple GBM and focuses on the heterogeneity spread pathway, imaging diagnosis, pathology, molecular characterization and prognosis of multifocal and multicentric GBM. Several promising therapeutic methods of multiple GBM are also recommended.

Keywords: Glioblastoma; Glioma; Multicentric; Multifocal.

Publication types

Systematic Review

MeSH terms

Brain Neoplasms / diagnosis
Brain Neoplasms / pathology*
Brain Neoplasms / therapy
Glioblastoma / diagnosis
Glioblastoma / pathology*
Glioblastoma / therapy
Humans