Mini-review on the properties and possible applications of therapeutic oxygen carrier Hemarina-M101

Joseph Varney; Amanda Rivera; Vinh Dong; Paul Tieu; Sairah Zia; Nguyen Tien Huy

doi:10.1016/j.transci.2020.103016

Mini-review on the properties and possible applications of therapeutic oxygen carrier Hemarina-M101

Transfus Apher Sci. 2021 Feb;60(1):103016. doi: 10.1016/j.transci.2020.103016. Epub 2020 Nov 21.

Authors

Joseph Varney¹, Amanda Rivera², Vinh Dong³, Paul Tieu⁴, Sairah Zia⁵, Nguyen Tien Huy⁶

Affiliations

¹ American University of the Caribbean Medical School, Cupe Coy, Sint Maarten (Dutch Part). Electronic address: josephvarney@students.aucmed.edu.
² American University of the Caribbean Medical School, Cupe Coy, Sint Maarten (Dutch Part). Electronic address: amandarivera@gmail.com.
³ American University of the Caribbean Medical School, Cupe Coy, Sint Maarten (Dutch Part). Electronic address: vinhd091@gmail.com.
⁴ Faculty of Health Sciences, McMaster University, Canada. Electronic address: tieut@mcmaster.ca.
⁵ American University of the Caribbean Medical School, Cupe Coy, Sint Maarten (Dutch Part). Electronic address: sairahz1592@gmail.com.
⁶ School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan. Electronic address: tienhuy@nagasaki-u.ac.jp.

PMID: 33358088
DOI: 10.1016/j.transci.2020.103016

Abstract

Therapeutic Oxygen Carriers (TOCs) have been studied in the past for utilization in resuscitation fluid, treatment of organ ischemia, and as an alternative to red blood cell transfusion. One TOC, Hemarina-M101, seems promising in transplantation and oxygenation due its capability as a non-immunogenic, nontoxic, high-oxygen-carrying capacity TOC with little to no side effects. This mini-review focuses on Hemarina-M101 and explores its characteristics and possible utilities through past and recent studies.

Keywords: Arenicola marina; Hemarina-M101; Hemoglobin-based artificial oxygen carriers; TOCs; Therapeutic oxygen carriers.

Publication types

Review

MeSH terms

Erythrocyte Transfusion / methods*
Humans
Oxygen / chemistry*

Substances

Oxygen