Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application

Carbohydr Polym. 2021 Feb 15:254:117302. doi: 10.1016/j.carbpol.2020.117302. Epub 2020 Oct 26.

Abstract

Currently, special emphasis is being given to the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications. Herein, we report the synthesis and characterization of hydroxypropyl methylcellulose (HPMC) reinforced with HPMC capped copper nanoparticles (HCu NPs) based nanocomposite hydrogel films (NHFs). Spherical nanostructures of HCu NPs (∼40 nm) were achieved by facile precipitation technique using ascorbic acid as a nucleating agent and subsequently made their NHFs via solution casting method. Spectral, thermal and structural characteristics of the developed materials were carried out. Antibacterial activity of the resultant NHFs showed the MIC and MBC values of 350 and 1400 μg/mL for S. aureus, and 500 and 2000 μg/mL for E. coli, respectively. These results conveyed that the HCu NPs incorporated HPMC NHFs can be used effectively in antibacterial applications.

Keywords: Antibacterial activity; Hydrogel films; Non-ionic hydroxypropyl methylcellulose; Spherical copper nanoparticles.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Ascorbic Acid / chemistry
  • Bandages
  • Chemical Precipitation
  • Copper / chemistry*
  • Escherichia coli / drug effects
  • Hot Temperature
  • Hydrogels / chemistry*
  • Hypromellose Derivatives / chemistry*
  • Metal Nanoparticles / chemistry*
  • Methylgalactosides / chemistry*
  • Microbial Sensitivity Tests
  • Nanocomposites / chemistry*
  • Particle Size
  • Staphylococcus aureus / drug effects
  • Wound Healing / drug effects

Substances

  • Anti-Bacterial Agents
  • Hydrogels
  • Methylgalactosides
  • hydrogel film
  • Hypromellose Derivatives
  • Copper
  • Ascorbic Acid