Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems

Antônia Carla de Jesus Oliveira; Luíse Lopes Chaves; Fábio de Oliveira Silva Ribeiro; Laís Ramos Monteiro de Lima; Thaisa Cardoso Oliveira; Fátima García-Villén; César Viseras; Regina C M de Paula; Pedro José Rolim-Neto; Fernando Hallwass; Edson C Silva-Filho; Durcilene Alves da Silva; José Lamartine Soares-Sobrinho; Mônica Felts de La Roca Soares

doi:10.1016/j.carbpol.2020.117226

Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems

Carbohydr Polym. 2021 Feb 15:254:117226. doi: 10.1016/j.carbpol.2020.117226. Epub 2020 Oct 23.

Authors

Antônia Carla de Jesus Oliveira¹, Luíse Lopes Chaves¹, Fábio de Oliveira Silva Ribeiro², Laís Ramos Monteiro de Lima³, Thaisa Cardoso Oliveira¹, Fátima García-Villén⁴, César Viseras⁵, Regina C M de Paula³, Pedro José Rolim-Neto⁶, Fernando Hallwass⁷, Edson C Silva-Filho⁸, Durcilene Alves da Silva², José Lamartine Soares-Sobrinho⁹, Mônica Felts de La Roca Soares¹

Affiliations

¹ Quality Control Core of Medicines and Correlates - NCQMC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil.
² Research Center on Biodiversity and Biotechnology - BIOTEC, Federal University of Delta of Parnaiba, Parnaiba, PI, Brazil.
³ Department of Organic and Inorganic Chemistry, Federal University of Ceara, Fortaleza, CE, Brazil.
⁴ Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain.
⁵ Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain; Andalusian Institute of Earth Sciences, CSIC - UGR, Armilla, Granada, Spain.
⁶ Laboratory of Technology of Medicines - LTM, Federal University of Pernambuco, Recife, Brazil.
⁷ Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, PE, Brazil.
⁸ Interdisciplinary Laboratory for Advanced Materials - LIMAV, Federal University of Piaui, Teresina, PI, Brazil.
⁹ Quality Control Core of Medicines and Correlates - NCQMC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: jose.ssobrinho@ufpe.br.

PMID: 33357841
DOI: 10.1016/j.carbpol.2020.117226

Abstract

Chemical modification of polysaccharides is an important approach for their transformation into customized matrices that suit different applications. Microwave irradiation (MW) has been used to catalyze chemical reactions. This study developed a method of MW-initiated synthesis for the production of phthalated cashew gum (Phat-CG). The structural characteristics and physicochemical properties of the modified biopolymers were investigated by FTIR, GPC, ¹H NMR, relaxometry, elemental analysis, thermal analysis, XRD, degree of substitution, and solubility. Phat-CG was used as a matrix for drug delivery systems using benznidazole (BNZ) as a model drug. BNZ is used in the pharmacotherapy of Chagas disease. The nanoparticles were characterized by size, PDI, zeta potential, AFM, and in vitro release. The nanoparticles had a size of 288.8 nm, PDI of 0.27, and zeta potential of -31.8 mV. The results showed that Phat-CG has interesting and promising properties as a new alternative for improving the treatment of Chagas disease.

Keywords: Benznidazole; Chemical modification; Microwave irradiation; Polymeric nanoparticles; Polysaccharides.

MeSH terms

Anacardium / chemistry*
Chagas Disease / drug therapy
Computer Simulation
Drug Delivery Systems*
Humans
In Vitro Techniques
Magnetic Resonance Spectroscopy
Microscopy, Atomic Force
Microwaves
Molecular Structure
Nanoparticles / chemistry
Nitroimidazoles / administration & dosage
Particle Size
Phthalic Acids / chemistry
Plant Gums / chemistry*
Spectroscopy, Fourier Transform Infrared
Trypanocidal Agents / administration & dosage

Substances

Nitroimidazoles
Phthalic Acids
Plant Gums
Trypanocidal Agents
phthalic acid
benzonidazole