Lung cancer is the most common malignant tumor with the highest morbidity and mortality worldwide, and its imposes an insupportable burden on patients due to its poor prognosis. The diagnosis and treatment of lung cancer is under great pressure. Therefore, it is urgent to explore effective therapeutic targets and molecular markers. Circular RNA (circRNA) is a kind of covalently closed non-coding RNAs, which has attracted much attention due to its conservation, stability and tissue specificity. Many studies have found that circRNA participates in the regulation of lung cancer through various mechanisms such as sponging miRNA and plays a part vital role in the early diagnosis, treatment and prognosis evaluation. In recent years, there have been numerous studies on circRNA in lung cancer. This paper summarizes the current progress of circRNA in the diagnosis, treatment and prognosis of lung cancer. .
【中文题目：环状RNA在肺癌中的研究进展】 【中文摘要：肺癌是全球发病率和死亡率最高的恶性肿瘤，其较差的预后结局为患者带来了沉重的负担。目前肺癌诊疗面临的形势依然严峻，亟待探寻有效的治疗靶点及分子标志物。环状RNA（circular RNA, circRNA）是共价闭合的非编码RNA，因其保守性、稳定性、组织特异性等生物学特性而备受关注。诸多研究发现环状RNA通过吸附miRNA等多种机制参与肺癌的调控，并对肺癌的早期诊断、治疗及预后评价发挥重要作用。近年来，circRNA在肺癌的相关研究层出不穷。本文就目前circRNA在肺癌诊断、治疗以及预后方面的进展予以归纳总结。 】 【中文关键词：环状RNA；肺肿瘤；诊断；治疗；预后】.
Keywords: Circular RNA; Diagnosis; Lung neoplasms; Prognosis; Treatment.