Complexity of host-vector dynamics in a two-strain dengue model

J Biol Dyn. 2021 Dec;15(1):35-72. doi: 10.1080/17513758.2020.1864038.

Abstract

We introduce a compartmental host-vector model for dengue with two viral strains, temporary cross-immunity for the hosts, and possible secondary infections. We study the conditions on existence of endemic equilibria where one strain displaces the other or the two virus strains co-exist. Since the host and vector epidemiology follow different time scales, the model is described as a slow-fast system. We use the geometric singular perturbation technique to reduce the model dimension. We compare the behaviour of the full model with that of the model with a quasi-steady approximation for the vector dynamics. We also perform numerical bifurcation analysis with parameter values from the literature and compare the bifurcation structure to that of previous two-strain host-only models.

Keywords: 35B32; 37N25; 92D30; Dengue; Vector-borne disease dynamics; bifurcation analysis; two-strain model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coinfection*
  • Dengue*
  • Disease Vectors
  • Humans
  • Models, Biological