A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (Cav.) Cabrera leaves

Heba A S El-Nashar; Nada M Mostafa; Omayma A Eldahshan; Abdel Nasser B Singab

doi:10.1080/14786419.2020.1864365

A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (Cav.) Cabrera leaves

Nat Prod Res. 2022 Mar;36(5):1182-1190. doi: 10.1080/14786419.2020.1864365. Epub 2020 Dec 28.

Authors

Heba A S El-Nashar¹, Nada M Mostafa¹, Omayma A Eldahshan^{1

2}, Abdel Nasser B Singab^{1

2}

Affiliations

¹ Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
² Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt.

PMID: 33356557
DOI: 10.1080/14786419.2020.1864365

Abstract

A new biflavonoid, luteolin-(6→8'')-apigenin was isolated from 80% methanol extract of Schinus polygama (Cav.) Cabrera leaves (Anacardiaceae). The structure was elucidated by 1D and 2D-NMR spectroscopic data. This compound exhibited in vitro antidiabetic effect via α-amylase assay. Furthermore, it possesses anti-inflammatory activity through membrane stabilization effect on erythrocytes.

Keywords: Schinus polygama; amylase; anti-inflammatory; biflavonoid; membrane stabilization.

MeSH terms

Anacardiaceae* / chemistry
Anti-Inflammatory Agents / analysis
Anti-Inflammatory Agents / pharmacology
Biflavonoids* / pharmacology
Hypoglycemic Agents / analysis
Hypoglycemic Agents / pharmacology
Plant Extracts / chemistry
Plant Leaves / chemistry

Substances

Anti-Inflammatory Agents
Biflavonoids
Hypoglycemic Agents
Plant Extracts