Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease

Milica Stojkovic Lalosevic; Ljubisa Toncev; Sanja Stankovic; Sanja Dragasevic; Stefan Stojkovic; Ivana Jovicic; Milos Stulic; Djordje Culafic; Tamara Milovanovic; Marija Stojanovic; Marko Aleksic; Mihailo Stjepanovic; Jovan Lalosevic; Stanimir Kiurski; Branislav Oluic; Aleksandra Pavlovic Markovic; Mirjana Stojkovic

doi:10.1155/2020/8523205

Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease

Dis Markers. 2020 Nov 28:2020:8523205. doi: 10.1155/2020/8523205. eCollection 2020.

Authors

Milica Stojkovic Lalosevic^{1

2}, Ljubisa Toncev¹, Sanja Stankovic³, Sanja Dragasevic^{1

2}, Stefan Stojkovic¹, Ivana Jovicic¹, Milos Stulic¹, Djordje Culafic^{1

2}, Tamara Milovanovic^{1

2}, Marija Stojanovic², Marko Aleksic², Mihailo Stjepanovic², Jovan Lalosevic², Stanimir Kiurski¹, Branislav Oluic², Aleksandra Pavlovic Markovic^{1

2}, Mirjana Stojkovic^{1

2}

Affiliations

¹ Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.
² Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
³ Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.

Abstract

Results: There was a high statistically significant difference between IBD patients and controls in levels of hepcidin (P < 0.01). Namely, serum hepcidin levels were significantly higher in the control group. There was no statistically significant correlation of serum hepcidin with CRP, Mayo score, or CDAI, respectively (P > 0.05). However, we have found a statistically significant negative correlation of sTfR and TIBC with hepcidin (P < 0.01).

Conclusion: Results of our study suggest that hepcidin is a reliable marker of IDA in patients with IBD, and it could be used in routine clinical practice when determining adequate therapy in these patients.

MeSH terms

Adult
Anemia, Iron-Deficiency / blood*
Anemia, Iron-Deficiency / etiology*
Biomarkers / blood
Blood Cell Count
Case-Control Studies
Female
Ferritins / blood
Hepcidins / blood*
Humans
Inflammatory Bowel Diseases / complications*
Male
Middle Aged

Substances

Biomarkers
HAMP protein, human
Hepcidins
Ferritins