Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)

B Kopp; S Mein; T Tessonnier; J Besuglow; S Harrabi; E Heim; A Abdollahi; T Haberer; J Debus; A Mairani

doi:10.1016/j.ejmp.2020.11.028

Rapid effective dose calculation for raster-scanning ⁴He ion therapy with the modified microdosimetric kinetic model (mMKM)

Phys Med. 2021 Jan:81:273-284. doi: 10.1016/j.ejmp.2020.11.028. Epub 2021 Jan 19.

Authors

B Kopp¹, S Mein², T Tessonnier³, J Besuglow¹, S Harrabi⁴, E Heim⁵, A Abdollahi², T Haberer³, J Debus⁶, A Mairani⁷

Affiliations

¹ Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.
² Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
⁴ German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
⁵ Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
⁶ German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
⁷ Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; National Centre of Oncological Hadrontherapy (CNAO), Medical Physics, Pavia, Italy. Electronic address: Andrea.Mairani@med.uni-heidelberg.de.

PMID: 33353795
DOI: 10.1016/j.ejmp.2020.11.028

Abstract

Purpose: To develop and verify effective dose (D_RBE) calculation in ⁴He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine.

Methods: Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC) simulations for ⁴He-ion beams. Relative biological effectiveness (RBE) and D_RBE calculation using MRFS were established within a fast analytical engine. Spread-out Bragg-Peaks (SOBPs) in water were optimized for two dose levels and two tissue types with photon linear-quadratic model parameters α_ph, β_ph, and (α/β)_ph to verify MRFS-derived database implementation against computations with MC-generated mixed-field α and β databases. Bio-sensitivity of the SOBPs was investigated by varying absolute values of β_ph, while keeping (α/β)_ph constant. Additionally, dose, dose-averaged linear energy transfer, and bio-sensitivity were investigated for two patient cases.

Results: Using MRFS-derived databases, dose differences ≲2% in the plateau and SOBP are observed compared to computations with MC-generated databases. Bio-sensitivity studies show larger deviations when altering the absolute β_ph value, with maximum D_50% changes of ~5%, with similar results for patient cases. Bio-sensitivity analysis indicates a greater impact on D_RBE varying (α/β)_ph than β_ph in mMKM.

Conclusions: The MRSF approach yielded negligible differences in the target and small differences in the plateau compared to MC-generated databases. The presented analyses provide guidance for proper implementation of RBE-weighted ⁴He ion dose prescription and planning with mMKM. The MRFS-D_RBE calculation approach using mMKM will be implemented in a clinical treatment planning system.

Keywords: Biological model; FRoG/PRECISE; Heidelberg Ion-Beam Therapy Center; Helium ion therapy.

MeSH terms

Heavy Ion Radiotherapy*
Humans
Linear Energy Transfer
Monte Carlo Method
Proton Therapy*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Relative Biological Effectiveness