Sperm genetic abnormalities and their contribution to embryo aneuploidy & miscarriage

Best Pract Res Clin Endocrinol Metab. 2020 Dec;34(6):101477. doi: 10.1016/j.beem.2020.101477. Epub 2020 Dec 1.

Abstract

Sperm genetic testing has been proposed for clinical diagnosis of possible causes of male infertility. We reviewed the most remarkable publications of sperm DNA integrity and sperm aneuploidy as they relate to clinical outcomes, and the relationship between both genetic defects, and its association to embryo aneuploidy and recurrent pregnancy loss.

Keywords: aneuploidy; embryo; fragmentation; miscarriage; sperm.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual / diagnosis
  • Abortion, Habitual / genetics*
  • Aneuploidy*
  • DNA Fragmentation
  • Female
  • Genetic Diseases, Inborn / complications
  • Genetic Diseases, Inborn / diagnosis
  • Genetic Diseases, Inborn / embryology
  • Genetic Diseases, Inborn / genetics
  • Genetic Testing
  • Humans
  • Infertility, Male / diagnosis
  • Infertility, Male / genetics*
  • Male
  • Pregnancy
  • Spermatozoa / abnormalities
  • Spermatozoa / metabolism*
  • Spermatozoa / pathology