From 3D Back to 2D Monolayer Stomach Organoids-on-a-Chip

Phatcharida Jantaree; Liubov Bakhchova; Ulrike Steinmann; Michael Naumann

doi:10.1016/j.tibtech.2020.11.013

From 3D Back to 2D Monolayer Stomach Organoids-on-a-Chip

Trends Biotechnol. 2021 Aug;39(8):745-748. doi: 10.1016/j.tibtech.2020.11.013. Epub 2020 Dec 19.

Authors

Phatcharida Jantaree¹, Liubov Bakhchova², Ulrike Steinmann², Michael Naumann³

Affiliations

¹ Institute of Experimental Internal Medicine, Medical Faculty, Otto von Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany.
² Institute for Automation Technology, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
³ Institute of Experimental Internal Medicine, Medical Faculty, Otto von Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany. Electronic address: Naumann@med.ovgu.de.

PMID: 33353764
DOI: 10.1016/j.tibtech.2020.11.013

Abstract

2D monolayer gastric organoids (2DMGOs)-on-a-chip have consistent structures and can live for more than a year in culture. This state-of-the-art cell physiological system in a microfluidic device provides a way to investigate biomedically relevant, stimuli-dependent cellular responses in a variety of differentiated 2DMGOs.

Keywords: Helicobacter pylori; drug screening; gastric cancer; microfluidic device; personalized medicine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomedical Research / instrumentation
Biomedical Research / methods
Humans
Lab-On-A-Chip Devices*
Organoids* / physiology
Physiology* / instrumentation
Physiology* / methods
Stomach* / physiology