Modulatory mechanisms of NLRP3: Potential roles in inflammasome activation

Life Sci. 2021 Feb 15:267:118918. doi: 10.1016/j.lfs.2020.118918. Epub 2020 Dec 19.

Abstract

The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studies have focused on specifically targeting NLRP3 to develop inhibitors against NLRP3 inflammasome. Here, we succinctly review the regulation of NLRP3 expression at DNA/chromosome, transcriptional, post-transcriptional, and translation levels. These are critical for the fine regulation of the NLRP3 inflammasome.

Keywords: Expression Regulation; Histone Modification; NLRP3; Non-coding RNAs.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Humans
  • Immunity, Innate / immunology
  • Inflammasomes / metabolism
  • Inflammasomes / physiology
  • Inflammation / immunology
  • Macrophages / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein / physiology*
  • Signal Transduction

Substances

  • Cytokines
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein