Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL)

Isabelle Jalenques; Diane Cyrille; Philippe Derost; Andreas Hartmann; Sophie Lauron; Clara Jameux; Urbain Tauveron-Jalenques; Candy Guiguet-Auclair; Fabien Rondepierre; Syndrome de Gilles de La Tourette Study Group

doi:10.1371/journal.pone.0243912

Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL)

PLoS One. 2020 Dec 22;15(12):e0243912. doi: 10.1371/journal.pone.0243912. eCollection 2020.

Authors

Isabelle Jalenques¹, Diane Cyrille¹, Philippe Derost², Andreas Hartmann³, Sophie Lauron¹, Clara Jameux¹, Urbain Tauveron-Jalenques¹, Candy Guiguet-Auclair⁴, Fabien Rondepierre¹; Syndrome de Gilles de La Tourette Study Group

Affiliations

¹ Centre de Compétence Gilles de la Tourette, Service de Psychiatrie de l'Adulte A et Psychologie Médicale, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
² Service de Neurologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
³ Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, National Reference Center for Tourette Syndrome, Paris, France.
⁴ Université Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut Pascal, Clermont-Ferrand, France.

Abstract

Introduction: The Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL) is a self-rated disease-specific questionnaire to assess health-related quality of life of subjects with GTS. Our aim was to perform the cross-cultural adaptation of the GTS-QOL into French and to assess its psychometric properties.

Methods: The GTS-QOL was cross-culturally adapted by conducting forward and backward translations, following international guidelines. The psychometric properties of the GTS-QOL-French were assessed in 109 participants aged 16 years and above with regard to factor structure, internal consistency, reliability and convergent validity with the MOVES (Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey) and the WHOQOL-BREF (World Health Organization Quality of Life Brief).

Results: Exploratory factor analysis of the GTS-QOL-French resulted in a 6-factor solution and did not replicate the original structure in four subscales. The results showed good acceptability (missing values per subscale ranging from 0% to 0.9%), good internal consistency (Cronbach's alpha ranging from 0.68 to 0.94) and good test-retest reliability (intraclass correlation coefficients ranging from 0.70 to 0.81). Convergent validity with the MOVES and WHOQOL-BREF scales showed high correlations.

Discussion: Our study provides evidence of the good psychometric properties of the GTS-QOL-French. The cross-cultural adaptation and validation of this specific instrument will make it possible to assess health-related quality of life in French-speaking subjects with GTS. The GTS-QOL-French could be recommended for use in future research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Compulsive Behavior / physiopathology*
Cross-Cultural Comparison
Female
Humans
Male
Middle Aged
Psychometrics / methods*
Quality of Life
Surveys and Questionnaires
Tourette Syndrome / diagnosis*
Tourette Syndrome / epidemiology
Tourette Syndrome / physiopathology
World Health Organization
Young Adult

Grants and funding

IJ received a grant from the University Hospital of Clermont-Ferrand (AOI 2012) and the Association Française Syndrome Gilles de la Tourette (AO AFSGT 2015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.