[Advances in studies on steroidal alkaloids and their pharmacological activities in genus Veratrum]

Zhongguo Zhong Yao Za Zhi. 2020 Nov;45(21):5129-5142. doi: 10.19540/j.cnki.cjcmm.20200612.201.
[Article in Chinese]

Abstract

Genus Veratrum plants contain a diversity of steroidal alkaloids, so far at least 184 steroidal alkaloids attributed to cevanine type(A-1~A-69), veratramine type(B-1~B-21), jervanine type(C-1~C-31), solanidine type(D-1~D-10) and verazine type(E-1~E-53), respectively, have been isolated and identified in the genus Veratrum. Their pharmacological activities mainly focused on decreasing blood pressure, anti-platelet aggregation and anti-thrombosis, anti-inflammatory and analgesic, and antitumor effect. This paper classified and summarized the 184 kind of steroidal alkaloids from the Veratrum plants and their major pharmalogical activities in order to provide the scientific basis for the further development and utilization of active alkaloids.

Keywords: chemical constituents; genus Veratrum; pharmalogical activities; steroidal alkaloids.

MeSH terms

  • Alkaloids* / pharmacology
  • Analgesics
  • Platelet Aggregation
  • Steroids / pharmacology
  • Veratrum*

Substances

  • Alkaloids
  • Analgesics
  • Steroids