Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Xinyu Xiong; Zhe Cheng; Fan Wu; Meilin Hu; Zhimin Liu; Ruolan Dong; Guang Chen

doi:10.1016/j.biopha.2020.111129

Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Biomed Pharmacother. 2021 Feb:134:111129. doi: 10.1016/j.biopha.2020.111129. Epub 2020 Dec 24.

Authors

Xinyu Xiong¹, Zhe Cheng¹, Fan Wu², Meilin Hu¹, Zhimin Liu³, Ruolan Dong¹, Guang Chen⁴

Affiliations

¹ Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
² Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
³ Department of Coloproctology, The Sixth Affiliated Hospital of Sun Yat-sen University (Gastrointestinal & Anal Hospital of Sun Yat-sen University), Guangzhou 510655, China.
⁴ Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: guangchen@tjh.tjmu.edu.cn.

PMID: 33348308
DOI: 10.1016/j.biopha.2020.111129

Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.

Keywords: Berberine; Bitter taste receptor; Intestinal stem cell; Tuft cell; Ulcerative colitis.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents / therapeutic use*
Berberine / therapeutic use*
Colitis, Ulcerative / drug therapy*
Colitis, Ulcerative / immunology
Colitis, Ulcerative / metabolism
Colitis, Ulcerative / pathology
Colon / drug effects*
Colon / immunology
Colon / metabolism
Colon / pathology
Cytokines / metabolism
Humans
Inflammation Mediators / metabolism
Intestinal Mucosa / drug effects*
Intestinal Mucosa / metabolism
Intestinal Mucosa / pathology
Receptors, G-Protein-Coupled / agonists
Receptors, G-Protein-Coupled / metabolism
Signal Transduction
Stem Cells / drug effects*
Stem Cells / immunology
Stem Cells / metabolism
Stem Cells / pathology

Substances

Anti-Inflammatory Agents
Cytokines
Inflammation Mediators
Receptors, G-Protein-Coupled
taste receptors, type 1
taste receptors, type 2
Berberine