Seroprevalence and risk factors of Toxoplasma gondii infection in goats in China from 2010 to 2020: A systematic review and meta-analysis

Abstract

Toxoplasma gondii is a widely distributed protozoan parasite that can infect a variety of warm-blooded animals including humans and goats. This is the first meta-analysis to assess the overall seroprevalence and potential risk factors of T. gondii infection among goats in China. Databases including the VIP Chinese Journal Databases (VIP), the China National Knowledge Infrastructure (CNKI) database, WanFang, ScienceDirect, and PubMed were searched comprehensively for relevant studies published from 2010 to date. A random-effects model was used to calculate pooled seroprevalence estimates with 95 % confidence intervals (CI) and data were analyzed from 13 provinces in China. The pooled T. gondii seroprevalence in goats was estimated as 9.9 %. Goats T. gondii had the highest seroprevalence in Southwestern China (13.3 %) and the lowest in Northeastern China (7.3 %). The seroprevalence in the sub-group before 2012 (8.0 %) was lower than that in 2012-2015 (15.2 %) and 2016 or later (9.2 %). Goats aged > 12-months had a higher seroprevalence (11.7 %) than ≤ 12-months (10.7 %). The seroprevalence in female goats was 12.5 % and 12.2 % in male goats. In season subgroups, the seroprevalence was lowest in autumn (6.1 %). Naturally grazed goats had a seroprevalence of 8.1 % of infection and 7.8 % in intensively fed goats. We also evaluated the effects of geographical and climate variables on the pooled seroprevalence of T. gondii in goats in China. The results indicated that toxoplasmosis is widely distributed in goats in China. In the context of ensuring animal welfare, we suggest the continued promotion of the transition from natural grazing to intensive agriculture to strengthen disease prevention. Prevention would be better carried out in areas suitable for the survival and reproduction of T. gondii. Breeders need to regularly disinfect the feeding areas and pens or other areas of goat activity thoroughly to reduce the impact of environmental factors responses on the infection of goats to T. gondii.

Keywords: Goats; Meta-analysis; Seroprevalence; Toxoplasma gondii; Toxoplasmosis; Zoonosis.