Targeted nanomedicines for the treatment of bone disease and regeneration

Farideh Ordikhani; Nooshin Zandi; Mozhdeh Mazaheri; Gaurav A Luther; Mahsa Ghovvati; Abolfazl Akbarzadeh; Nasim Annabi

doi:10.1002/med.21759

Targeted nanomedicines for the treatment of bone disease and regeneration

Med Res Rev. 2021 May;41(3):1221-1254. doi: 10.1002/med.21759. Epub 2020 Dec 21.

Authors

Farideh Ordikhani¹, Nooshin Zandi^{2

3}, Mozhdeh Mazaheri⁴, Gaurav A Luther⁵, Mahsa Ghovvati⁶, Abolfazl Akbarzadeh^{3

7}, Nasim Annabi⁶

Affiliations

¹ Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran.
³ Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.
⁴ Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
⁵ Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁶ Department of Chemical and Biomolecular Engineering, University of California- Los Angeles, California, Los Angeles, USA.
⁷ Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 33347711
DOI: 10.1002/med.21759

Abstract

Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone-targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical applications. In the present review, the latest advancements in targeting moieties and nanocarrier drug delivery systems for the treatment of bone diseases are summarized. We also review the regeneration capability and effective delivery of nanomedicines for orthopedic applications.

Keywords: bone regeneration; nanomedicine; orthopedics; targeted drug delivery.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Carriers
Drug Delivery Systems
Humans
Nanomedicine
Nanoparticles*
Osteoporosis*

Substances

Drug Carriers

Abstract

Publication types

MeSH terms

Substances

Grants and funding