Modular Assembly of Drug and Monodisperse SPIONs for Superior Magnetic and T2-Imaging Performance

Huan Shen; Ergang Liu; Shijie Xu; Weiwei Tang; Jie Sun; Zhenguo Gao; Junbo Gong

doi:10.1021/acs.bioconjchem.0c00597

Modular Assembly of Drug and Monodisperse SPIONs for Superior Magnetic and T₂-Imaging Performance

Bioconjug Chem. 2021 Jan 20;32(1):182-191. doi: 10.1021/acs.bioconjchem.0c00597. Epub 2020 Dec 21.

Authors

Huan Shen¹, Ergang Liu², Shijie Xu³, Weiwei Tang¹, Jie Sun¹, Zhenguo Gao¹, Junbo Gong¹

Affiliations

¹ School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China.
² Zhongshan Branch, the Institute of Drug Research and Development, Chinese Academy of Sciences, Zhongshan 528451, China.
³ College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, China.

PMID: 33346657
DOI: 10.1021/acs.bioconjchem.0c00597

Abstract

Development of superparamagnetic iron oxide nanoparticles (SPIONs) based theranostics has suffered due to its self-contradictory requirements on water dispersity and drug loadings. Generally well-dispersed SPIONs have excellent MRI performance but are insensitive to magnetism mediated delivery. Besides, loading hydrophobic drugs also hampers the stability of SPIONs which is critical for their biomedical applications. Considering these aspects, we employed curcumin as a cross-linking agent to facilitate the modular assembly of drug and monodisperse SPIONs (Cur/ALN-β-CD-SPIONs). Interestingly, the saturation magnetization of Cur/ALN-β-CD-SPIONs is higher than that of ALN-β-CD-SPIONs, and the value of r₂ indicating the negative contrast ability increases to 389.96 mM^-1 s^-1. Furthermore, the Cur/ALN-β-CD-SPIONs are very stable in PBS buffer over 3 weeks. The mice treated with Cur/ALN-β-CD-SPIONs by tail vein injection displayed a better tumor inhibition effect than that of free curcumin. This study provides a simple method for modular assembly of drug and monodisperse SPIONs, which is crucial to the design of SPIONs with superior T₂-imaging performance and drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Contrast Media / chemistry
Drug Screening Assays, Antitumor
Humans
Hydrophobic and Hydrophilic Interactions
Magnetic Resonance Imaging / methods
Magnetite Nanoparticles / chemistry*
Mice
Microscopy, Electron, Transmission
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction

Substances

Contrast Media
Magnetite Nanoparticles