Role of RhoA-ROCK signaling in Parkinson's disease

Eur J Pharmacol. 2021 Mar 5:894:173815. doi: 10.1016/j.ejphar.2020.173815. Epub 2020 Dec 17.

Abstract

Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathophysiological mechanisms of PD. RhoA-ROCK signals appear to have an important role in PD symptoms, making it a possible approach for PD treatment strategies. Activation of RhoA-ROCK (Rho-associated coiled-coil containing protein kinase) appears to stimulate various PD risk factors including aggregation of alpha-synuclein (αSyn), dysregulation of autophagy, and activation of apoptosis. This manuscript reviews current updates about the biology and function of the RhoA-ROCK pathway and discusses the possible role of this signaling pathway in causing the pathogenesis of PD. We conclude that inhibition of the RhoA-ROCK signaling pathway may have high translational potential and could be a promising therapeutic target in PD.

Keywords: Disease target; Dopamine; Neurodegenerative disease; Parkinson's Disease; RhoA-ROCK; Signaling pathways; Therapeutic strategy.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Humans
  • Microglia / metabolism
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / etiology*
  • Signal Transduction* / drug effects
  • alpha-Synuclein / metabolism
  • rho-Associated Kinases / antagonists & inhibitors
  • rho-Associated Kinases / chemistry
  • rho-Associated Kinases / physiology*
  • rhoA GTP-Binding Protein / agonists
  • rhoA GTP-Binding Protein / antagonists & inhibitors
  • rhoA GTP-Binding Protein / physiology*

Substances

  • alpha-Synuclein
  • rho-Associated Kinases
  • rhoA GTP-Binding Protein