Predicting Metabolite-Disease Associations Based on Spy Strategy and ABC Algorithm

Abstract

In recent years, latent metabolite-disease associations have been a significant focus in the biomedical domain. And more and more experimental evidence has been adduced that metabolites correlate with the diagnosis of complex human diseases. Several computational methods have been developed to detect potential metabolite-disease associations. In this article, we propose a novel method based on the spy strategy and an artificial bee colony (ABC) algorithm for metabolite-disease association prediction (SSABCMDA). Due to the fact that there are large parts of missing associations in unconfirmed metabolite-disease pairs, spy strategy is adopted to extract reliable negative samples from unconfirmed pairs. Considering the effects of parameters, the ABC algorithm is utilized to optimize parameters. In relevant cross-validation experiments, our method achieves excellent predictive performance. Moreover, three types of case studies are conducted on three common diseases to demonstrate the validity and utility of SSABCMDA method. Relevant experimental results indicate that our method can predict potential associations between metabolites and diseases effectively.

Keywords: ABC algorithm; associations; disease; metabolites; spy strategy.