Low potential detection of antiprotozoal drug metronidazole with aid of novel dysprosium vanadate incorporated oxidized carbon nanofiber modified disposable screen-printed electrode

Abstract

In this work, we designed tetragonal nanogravel structured dysprosium vanadate Dy(VO₄) nanoparticles unified with oxidized carbon nanofiber (f-CNF) denoted as Dy(VO₄)/f-CNF nanocomposite for the low potential determination of antiprotozoal drug metronidazole (MEZ). The physicochemical properties of novel Dy(VO₄)/f-CNF nanocomposite were analyzed through microscopic and spectroscopic techniques and obtained results express nanocomposite formed with desired surface morphology, crystalline phase, atomic vibrational modes, and preferred elemental compositions. The electrocatalytic activity of Dy(VO₄)/f-CNF nanocomposite was examined with a disposable screen-printed electrode (SPCE) via cyclic voltammetry (CV) and linear sweep voltammetry technique (LSV) with a conventional three-electrode system. Dy(VO₄)/f-CNF/SPCE delivers a higher active surface area recommends superior electrocatalytic activity which is favorable for the MEZ sensor. Electrocatalytic reduction of MEZ occurred with lower reduction potential (-0.55 V) with dynamic linear range (1.5-1036.9 µM), lower detection limit (6 nm), LOQ (0.022 µM), and higher sensitivity (1.12 μA μM^-1 cm²). The anti-interference studies retain its actual current without any shift in cathodic potential. Besides, the practical feasibility outcomes with higher cathodic current with the higher recovery rate and RSD in human blood sample, urine sample, and lake water as a real samples. Thus, Dy(VO₄)/f-CNF nanocomposite modified SPCE considers being a potential candidate for the MEZ sensor.

Keywords: Dysprosium vanadate; Linear sweep voltammetry; Metronidazole; Nanogravel; Oxidized carbon nanofiber.