CAR trafficking does matter: prospects of 'Chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy'

J Mol Cell Biol. 2020 Sep 1;12(9):745-746. doi: 10.1093/jmcb/mjaa045.

Authors

Wentao Li^{1

2

3}, Han Yang¹, Li Li¹, Haopeng Wang¹

Affiliations

¹ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
³ University of Chinese Academy of Sciences, Beijing 100049, China.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Neoplasm / metabolism
Antineoplastic Agents / metabolism*
Down-Regulation*
Endocytosis
Humans
Immunologic Memory
Receptors, Chimeric Antigen / metabolism*
T-Lymphocytes / immunology
Ubiquitination*

Substances

Antigens, Neoplasm
Antineoplastic Agents
Receptors, Chimeric Antigen