A Crisp(r) New Perspective on SARS-CoV-2 Biology

Adam L Bailey; Michael S Diamond

doi:10.1016/j.cell.2020.12.003

A Crisp(r) New Perspective on SARS-CoV-2 Biology

Cell. 2021 Jan 7;184(1):15-17. doi: 10.1016/j.cell.2020.12.003. Epub 2020 Dec 17.

Authors

Adam L Bailey¹, Michael S Diamond²

Affiliations

¹ Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: albailey@wisc.edu.
² Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: diamond@wusm.wustl.edu.

Abstract

Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other coronaviruses enhances our understanding of the cellular life cycle of this medically important family of emerging viruses.

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