Relationship of Telomere Length to Fat Redistribution in HIV

Sanjna Iyengar; Hélène C F Cȏté; Kathleen V Fitch; Martin Torriani; Meghan Feldpausch; Suman Srinivasa

doi:10.1093/ofid/ofaa523

Relationship of Telomere Length to Fat Redistribution in HIV

Open Forum Infect Dis. 2020 Oct 27;7(12):ofaa523. doi: 10.1093/ofid/ofaa523. eCollection 2020 Dec.

Authors

Sanjna Iyengar¹, Hélène C F Cȏté², Kathleen V Fitch¹, Martin Torriani^{1

3}, Meghan Feldpausch¹, Suman Srinivasa¹

Affiliations

¹ Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
³ Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Persons with HIV demonstrate increased risk for aging-associated complications and have reduced telomere length (TL) compared with age-matched persons without HIV. Our data show that greater visceral fat is related to reduced TL in HIV, independent of age and smoking. Fat redistribution may be a relevant mediator of TL attrition in HIV.

Keywords: BMI; HIV; telomere length; visceral adipose tissue; visceral fat.

Abstract

Grants and funding