Osteoporosis in Inflammatory Arthritides: New Perspective on Pathogenesis and Treatment

Denise Rotta; Angelo Fassio; Maurizio Rossini; Alessandro Giollo; Ombretta Viapiana; Giovanni Orsolini; Eugenia Bertoldo; Davide Gatti; Giovanni Adami

doi:10.3389/fmed.2020.613720

Osteoporosis in Inflammatory Arthritides: New Perspective on Pathogenesis and Treatment

Front Med (Lausanne). 2020 Dec 1:7:613720. doi: 10.3389/fmed.2020.613720. eCollection 2020.

Authors

Denise Rotta¹, Angelo Fassio¹, Maurizio Rossini¹, Alessandro Giollo¹, Ombretta Viapiana¹, Giovanni Orsolini¹, Eugenia Bertoldo¹, Davide Gatti¹, Giovanni Adami¹

Affiliation

¹ Rheumatology Unit, University of Verona, Verona, Italy.

Abstract

Osteoporosis is a skeletal disorder characterized by impaired bone strength and increased risk of fragility fracture and is among the most relevant comorbidities of rheumatic diseases. The purpose of the present review is to discuss the pathogenesis of local and systemic bone involvement in inflammatory arthritides, especially Rheumatoid Arthritis, Psoriatic Arthritis, and Spondyloarthritides, as well as the effect of anti-rheumatic treatments and anti-osteoporotic medication on bone health and fracture incidence, including recent data on novel therapeutic perspective.

Keywords: bone mineral density; fractures; osteoporosis; psoriatic arthritis; rheumatoid arthritis; spondyloarthritis.

Publication types

Review