Presynaptic and postsynaptic long-term plasticity in sleep homeostasis

Sheng Huang; Stephan J Sigrist

doi:10.1016/j.conb.2020.11.010

Presynaptic and postsynaptic long-term plasticity in sleep homeostasis

Curr Opin Neurobiol. 2021 Aug:69:1-10. doi: 10.1016/j.conb.2020.11.010. Epub 2020 Dec 14.

Authors

Sheng Huang¹, Stephan J Sigrist²

Affiliations

¹ Institute for Biology/Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
² Institute for Biology/Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address: stephan.sigrist@fu-berlin.de.

PMID: 33333414
DOI: 10.1016/j.conb.2020.11.010

Abstract

Sleep is an ancient and fundamental animal behavior. Sleep deprivation builds up sleep need to trigger recovery sleep, a homeostatic control crucial to maintain cognitive performance. Between several suggestions to explain the indispensable nature of sleep, restoration of synapse plasticity is a prominent one, though causal relations here remained scarce. In this review, we will discuss recent advances reporting a mutual functional interplay between sleep deprivation-associated synaptic changes and sleep homeostasis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Homeostasis
Neuronal Plasticity*
Sleep
Sleep Deprivation
Synapses*