Near-Infrared-II Semiconducting Polymer Dots for Deep-tissue Fluorescence Imaging

Nidhi Gupta; Yang-Hsiang Chan; Sampa Saha; Ming-Ho Liu

doi:10.1002/asia.202001348

Near-Infrared-II Semiconducting Polymer Dots for Deep-tissue Fluorescence Imaging

Chem Asian J. 2021 Feb 1;16(3):175-184. doi: 10.1002/asia.202001348. Epub 2020 Dec 28.

Authors

Nidhi Gupta^{1

2}, Yang-Hsiang Chan^{3

4}, Sampa Saha², Ming-Ho Liu⁵

Affiliations

¹ Department of Applied Chemistry, National Chiao Tung University, Hsinchu, 30010, Taiwan.
² Department of Materials Science and Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
³ Department of Applied Chemistry, Centre of Emergent Functional Matter Science, National Chiao Tung University, Hsinchu, 30010, Taiwan.
⁴ Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
⁵ Department of Applied Chemistry, National Chiao Tung University, 30010, Hsinchu City, Taiwan.

PMID: 33331122
DOI: 10.1002/asia.202001348

Abstract

Fluorescence imaging, particularly in the NIR-II region (1000-1700 nm), has become an unprecedented tool for deep-tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical properties, ultrahigh brightness, minimal autofluorescence, narrow-size distribution, and low cytotoxicity. This review elucidates the recent advances in Pdots for deep-tissue fluorescence imaging and the facing future translation to clinical use.

Keywords: NIR-II; deep-tissue; fluorescence; optical properties; polymer dots.

Publication types

Review

MeSH terms

Animals
Brain / diagnostic imaging
Infrared Rays*
Mice
Optical Imaging / methods*
Polymers / chemistry*
Quantum Dots / chemistry*
Semiconductors
Spectrometry, Fluorescence

Substances

Polymers

Abstract

Publication types

MeSH terms

Substances

Grants and funding