Lipid Metabolic Disorders and Ovarian Hyperstimulation Syndrome: A Retrospective Analysis

Feifei Liu; Qi Jiang; Xuedong Sun; Yuzhen Huang; Zhenzhen Zhang; Ting Han; Yuhua Shi

doi:10.3389/fphys.2020.491892

Lipid Metabolic Disorders and Ovarian Hyperstimulation Syndrome: A Retrospective Analysis

Front Physiol. 2020 Nov 19:11:491892. doi: 10.3389/fphys.2020.491892. eCollection 2020.

Authors

Feifei Liu^{1

2

3

4

5}, Qi Jiang^{1

2

3

4

5}, Xuedong Sun⁶, Yuzhen Huang^{1

2

3

4

5}, Zhenzhen Zhang^{1

2

3

4

5}, Ting Han^{1

2

3

4

5}, Yuhua Shi^{1

2

3

4

5}

Affiliations

¹ Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China.
³ Shandong Key Laboratory of Reproductive Medicine, Jinan, China.
⁴ Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China.
⁵ National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China.
⁶ Department of Neurology, Shandong Provincial Hospital, Jinan, China.

Abstract

Objectives: To evaluate the effect of dyslipidemia on the incidence of moderate and severe Ovarian hyperstimulation syndrome (OHSS) in the duration of assisted reproduction technique (ART).

Methods: The study included 233 moderate and severe OHSS patients who received hospitalization after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles to avoid severe complications. They were divided into dyslipidemia group and normal lipid metabolism group to evaluate whether dyslipidemia contributes to the development of severe OHSS. Subgroup analysis was set to avoid deviation including the freeze-all group and fresh embryo transfer (ET) group according to whether the eligible women chose fresh embryo transfer immediately after their IVF or ICSI cycles. The main outcome measures included the incidence of moderate OHSS and severe OHSS, total gonadotropin dose, number of oocytes retrieved, age and body mass index (BMI). In the ET groups, the rate of pregnancy is also included for analysis.

Results: In the freeze-all group, lipid metabolism was ultimately identified as the factor affecting the morbidity of severe OHSS and the ones with dyslipidemia were more likely to develop to severe OHSS (P < 0.05), while the incidence of severe OHSS among the ET groups had no statistical significance (P > 0.05).

Conclusion: The findings of this study suggested that dyslipidemia might contribute to the development of OHSS, especially for those patients who chose the cryopreservation of all embryos. It is essential to consider the risk of OHSS in patients with dyslipidemia although they required cryopreservation of all embryos.

Keywords: assisted reproductive technology; controlled ovarian hyperstimulation; freeze-all embryo; fresh embryo transfer; lipid metabolism disorders; ovarian hyperstimulation syndrome.