COVID-19 and haemodynamic failure: a point of view on mechanisms and treatment

Anaesthesiol Intensive Ther. 2020;52(5):409-417. doi: 10.5114/ait.2020.101813.

Abstract

The SARS-CoV-2-related disease has an undoubted impact on the healthcare system. In the treatment of severe COVID-19 cases, the main focus is on respiratory failure. However, available data suggest an important contribution of haemodynamic impairment in the course of this disease. SARS-CoV-2 may affect the circulatory system in various ways that are universal for septic conditions. Nonetheless, unique features of this pathogen, e.g. direct insult leading to myocarditis and renin-angiotensin-aldosterone axis dysregulation, must be taken into account. Although current recommendations on COVID-19 resemble previous septic shock guidelines, special attention to haemodynamic monitoring and treatment is necessary. Regarding treatment, one must take into account the potential profound hypovolaemia of severe COVID-19 patients. Pharmacological cardiovascular support should follow existing guidelines and practice. Interesting concepts of decatecholaminisation and the effect of vasopressors on pulmonary circulation are also presented in this review on COVID-19-related haemodynamic failure.

Keywords: COVID-19; SARS-CoV-2; cardiovascular.; critical care; hemodynamics.

Publication types

  • Review

MeSH terms

  • COVID-19 / complications
  • COVID-19 / physiopathology*
  • COVID-19 / therapy*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / therapy
  • Critical Care
  • Hemodynamic Monitoring
  • Hemodynamics*
  • Humans