The Role of Autophagy in Osteoarthritis

Ran Duan; Hui Xie; Zheng-Zhao Liu

doi:10.3389/fcell.2020.608388

The Role of Autophagy in Osteoarthritis

Front Cell Dev Biol. 2020 Nov 25:8:608388. doi: 10.3389/fcell.2020.608388. eCollection 2020.

Authors

Ran Duan^{1

2}, Hui Xie^{1

2

3

4

5

6}, Zheng-Zhao Liu^{1

2

3

4

5

6}

Affiliations

¹ Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
² Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China.
³ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
⁴ Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, China.
⁵ Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, China.
⁶ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.

Abstract

Chondrocytes are the only cell type in normal cartilage. The pathological changes of osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes. Autophagy, as an intracellular degradation system that maintains the steady state of energy metabolism in cells, has been shown to restore the function of damaged chondrocytes, alleviating the occurrence and progression of OA. In this review, we explored the relationship between autophagy and OA and the key molecules of autophagy pathway that regulate the progression of OA, providing new ideas for OA treatment by targeting autophagy.

Keywords: apoptosis; autophagy; cartilage; chondrocyte; osteoarthritis.

Publication types

Review