Bone Infarction Mimicking a Bone Metastasis on 18F-Prostate-Specific Membrane Antigen PET/CT

Clin Nucl Med. 2021 May 1;46(5):e250-e252. doi: 10.1097/RLU.0000000000003455.

Abstract

18F-prostate-specific membrane antigen (PSMA) PET/CT imaging is increasingly used in staging, assessment of biochemical recurrence, and treatment response in men with prostate cancer. We present a case report of a 70-year-old man who underwent 18F-PSMA PET/CT imaging to investigate biochemical recurrence following radical prostatectomy for prostate adenocarcinoma. New focal moderate PSMA uptake was identified in the left femur. A previous PSMA study, performed 5 months earlier, was normal. A subsequent MRI scan demonstrated that the PSMA avidity corresponded to a new femoral bone infarct. An English literature search revealed no previous cases of PSMA tracer uptake in bone infarction.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism*
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / metabolism
  • Bone Neoplasms / secondary*
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / pathology
  • Diagnosis, Differential
  • Fluorine Radioisotopes*
  • Glutamate Carboxypeptidase II / metabolism*
  • Humans
  • Infarction / diagnostic imaging*
  • Magnetic Resonance Imaging
  • Male
  • Positron Emission Tomography Computed Tomography*
  • Prostatectomy
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery

Substances

  • Antigens, Surface
  • Fluorine Radioisotopes
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II
  • Fluorine-18