Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

Mini Rev Med Chem. 2021;21(10):1152-1172. doi: 10.2174/1389557520999201214234735.

Abstract

Quinoline derivatives are considered broad-spectrum pharmacological compounds that exhibit a wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior. Due to its wide range of pharmaceutical applications, it is a very popular compound to design new drugs for the treatment of multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease and diabetes. In this review, our major focus is to pay attention to the biological activities of quinoline compounds in the treatment of these diseases such as anti-viral, anti-cancer, anti-malarial, antibacterial, anti-fungal, anti-tubercular and anti-diabetic.

Keywords: Quinoline derivatives; biologically active; broad spectrum; heterocyclic; inhibition.; pharmaceutical.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Alzheimer Disease / drug therapy
  • Dengue / drug therapy
  • Diabetes Mellitus / drug therapy
  • Humans
  • Malaria / drug therapy
  • Mycoses / drug therapy
  • Neoplasms / drug therapy*
  • Quinolines / chemical synthesis
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Tuberculosis / drug therapy

Substances

  • Quinolines