Survival Among Incident Peritoneal Dialysis Versus Hemodialysis Patients Who Initiate With an Arteriovenous Fistula

Purna Mukhopadhyay; Kenneth J Woodside; Douglas E Schaubel; Kaitlyn Repeck; Keith McCullough; Vahakn B Shahinian; Ronald L Pisoni; Rajiv Saran

doi:10.1016/j.xkme.2020.09.002

Survival Among Incident Peritoneal Dialysis Versus Hemodialysis Patients Who Initiate With an Arteriovenous Fistula

Kidney Med. 2020 Oct 22;2(6):732-741.e1. doi: 10.1016/j.xkme.2020.09.002. eCollection 2020 Nov-Dec.

Authors

Purna Mukhopadhyay¹, Kenneth J Woodside², Douglas E Schaubel³, Kaitlyn Repeck¹, Keith McCullough¹, Vahakn B Shahinian⁴, Ronald L Pisoni¹, Rajiv Saran^{4

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Affiliations

¹ Arbor Research Collaborative for Health, Ann Arbor, MI.
² Department of Surgery, University of Michigan, Ann Arbor, MI.
³ Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA.
⁴ Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
⁵ Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI.
⁶ Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.

Abstract

Rationale & objective: Comparisons of outcomes between in-center hemodialysis (HD) and peritoneal dialysis (PD) are confounded by selection bias because PD patients are typically younger and healthier and may have received longer predialysis care. We compared first-year survival between what we hypothesized were clinically equivalent groups; namely, patients who initiate maintenance HD using an arteriovenous fistula (AVF) and those selecting PD as their initial modality.

Study design: Observational, registry-based, retrospective cohort study.

Setting & participants: US Renal Data System data for 5 annual cohorts (2010-2014; n = 130,324) of incident HD with an AVF and incident PD patients.

Exposures and predictors: Exposure was more than 1 day receiving PD or more than 1 day receiving HD with an AVF. Time at risk for both cohorts was determined for 12 consecutive 30-day segments, censoring for transplantation, loss to follow-up, or end of time. Predictors included patient-level characteristics obtained from Centers for Medicare & Medicaid Services 2728 Form and other data sources.

Outcomes: Patient survival.

Analytical approach: Unadjusted and multivariable risk-adjusted HRs for death of HD versus PD patients, averaged over 2010 to 2014, were calculated.

Results: The HD cohort's average unadjusted mortality rate was consistently higher than for the PD cohort. The HR of HD versus PD was 1.25 (95% CI, 1.20-1.30) in the unadjusted model and 0.84 (95% CI, 0.80-0.87) in the adjusted model. However, multivariable risk-adjusted analyses showed the HR of HD versus PD for the first 90 days was 1.06 (95% CI, 0.98-1.14), decreasing to 0.74 (95% CI, 0.68-0.80) in the 270- to 360-day period.

Limitations: Residual confounding due to selection bias inherent in dialysis modality choice and the observational study design. Form 2728 provides baseline data at dialysis incidence alone, but not over time.

Conclusions: US patients receiving HD with an AVF appear to have a survival advantage over PD patients after 90 days of dialysis initiation after accounting for patient characteristics. These findings have implications in the choice of initial dialysis modality and vascular access for patients.

Keywords: Arteriovenous fistula; USRDS; chronic kidney disease; hemodialysis; patient outcomes; peritoneal dialysis; pre-ESRD care.