Abstract
A 48-year-old man with a history of schizophrenia was diagnosed with B-cell lymphoma of the small bowel. Neutropaenia occurred secondary to chemotherapy, which led to clozapine being discontinued, which resulted in the deterioration of his mental state, in turn, affecting the treatment of lymphoma. Clozapine was later reintroduced alongside granulocyte colony-stimulating factor, leading to improved mental state without any further incidences of neutropaenia.
Keywords:
chemotherapy; drugs: psychiatry; schizophrenia.
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
MeSH terms
-
Antineoplastic Agents / therapeutic use
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Antipsychotic Agents / adverse effects*
-
Antipsychotic Agents / therapeutic use
-
Clozapine / adverse effects*
-
Clozapine / therapeutic use
-
Drug Administration Schedule
-
Drug Therapy, Combination
-
Granulocyte Colony-Stimulating Factor / therapeutic use*
-
Humans
-
Lymphoma, B-Cell / drug therapy
-
Male
-
Middle Aged
-
Neutropenia / chemically induced*
-
Schizophrenia / blood
-
Schizophrenia / drug therapy*
-
Treatment Outcome
Substances
-
Antineoplastic Agents
-
Antipsychotic Agents
-
Granulocyte Colony-Stimulating Factor
-
Clozapine