Cross-cultural adaptation and psychometric validation of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire in French

Barbara Roux; Caroline Sirois; Anne Niquille; Anne Spinewine; Nicole Ouellet; Catherine Pétein; François-Xavier Sibille; Chantal Csajka; Emily Reeve; Claire Villeneuve; Marie-Laure Laroche

doi:10.1016/j.sapharm.2020.11.004

Cross-cultural adaptation and psychometric validation of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire in French

Res Social Adm Pharm. 2021 Aug;17(8):1453-1462. doi: 10.1016/j.sapharm.2020.11.004. Epub 2020 Nov 10.

Authors

Affiliations

¹ Centre of Pharmacovigilance and Pharmacoepidemiology, Department of Pharmacology-Toxicology and Centre of Pharmacovigilance, University Hospital of Limoges, Limoges, France; INSERM UMR 1248, Faculty of Medicine, University of Limoges, Limoges, France. Electronic address: barbara.roux@unilim.fr.
² Faculty of Medicine, Department of Social and Administrative Pharmacy, Laval University, Quebec, Canada; Centre of Excellence on Aging of Quebec, Quebec, Canada; Centre de Recherche sur les soins et les services de premières lignes de l'Université Laval, Quebec, Canada.
³ Community Pharmacy, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland; Community Pharmacy, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva, Switzerland; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University Hospital and University of Lausanne, Lausanne, Switzerland.
⁴ UCLouvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium; CHU UCL Namur, Pharmacy Department, Yvoir, Belgium.
⁵ Department of Nursing, University of Quebec at Rimouski, Rimouski, Canada.
⁶ UCLouvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium.
⁷ UCLouvain, Institute of Health and Society, Brussels, Belgium; CHU UCL Namur, Geriatric Medicine, Yvoir, Belgium.
⁸ Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University Hospital and University of Lausanne, Lausanne, Switzerland; School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
⁹ Quality Use of Medicines and Pharmacy Research Centre, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia; Geriatric Medicine Research, Faculty of Medicine, Dalhousie University and Nova Scotia Health Authority, Halifax, NS, Canada; College of Pharmacy, Dalhousie University, Halifax, NS, Canada.
¹⁰ Centre of Pharmacovigilance and Pharmacoepidemiology, Department of Pharmacology-Toxicology and Centre of Pharmacovigilance, University Hospital of Limoges, Limoges, France; INSERM UMR 1248, Faculty of Medicine, University of Limoges, Limoges, France.

PMID: 33317980
DOI: 10.1016/j.sapharm.2020.11.004

Abstract

Background: The revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire allows capture of the beliefs and attitudes of older adults and caregivers towards deprescribing.

Objectives: To translate and validate the rPATD questionnaire into French.

Methods: The French rPATD was translated using forward-backward translation. Psychometric properties were evaluated in both older adults ≥65 years living in the community or in institutions and who were taking at least one chronic medication and in caregivers of older adults with similar characteristics. Participants were recruited in four French-speaking countries (Belgium, Canada, France and Switzerland). Face and content validity were assessed during the translation process. Construct validity (exploratory factor analysis (EFA)) and internal consistency (Cronbach's alpha) were investigated in questionnaires without missing data. Test-retest reliability was evaluated using intra-class correlation coefficient (ICC) in a sample of participants.

Results: In total, 320 questionnaires from older adults and 215 questionnaires from caregivers were included to evaluate construct validity and internal consistency. EFA extracted four factors in the older adults' and caregivers' versions of the questionnaire consistent with the English rPATD. The extracted factors related to the perceived burden of medication taking, the beliefs in appropriateness of medications, concerns about stopping medications and the level of involvement in making decisions and of knowledge of medications. Internal consistency was satisfactory for three factors for both versions (Cronbach's alpha >0.70), with lower internal consistency in the concerns about stopping factor. Test-retest reliability was overall good for all factors in the caregivers' version (ICC > 0.75) while for the older adults' version, moderate (ICC range: 0.75-0.50) to good ICC values were found.

Conclusions: The French rPATD presents globally good psychometric properties and can be used to explore attitudes towards deprescribing in French-speaking older adults and caregivers.

Keywords: Caregivers; Cross-cultural adaptation; Deprescribing; French-language questionnaire; Older adults; Psychometric properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Attitude
Belgium
Canada
Cross-Cultural Comparison*
Deprescriptions*
France
Humans
Psychometrics
Reproducibility of Results
Surveys and Questionnaires
Switzerland