New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia

Fitoterapia. 2021 Jan:148:104805. doi: 10.1016/j.fitote.2020.104805. Epub 2020 Dec 11.

Abstract

Four new lignans, patulinones A-D (1-4) and three new acetophenone derivatives, patulinones E-G (5-7) were isolated from the leaves of Melicope patulinervia. Their structures were elucidated on the basis of the interpretation of HR-ESIMS, NMR, CD data. All the isolated compounds were evaluated for α-glucosidase inhibitory activity. Of the isolates, compound 4 was found to exhibit the strongest inhibition against α-glucosidase with IC50 value of 6.02 ± 0.46 μM.

Keywords: Acetophenone derivatives; Lignans; Melicope patulinervia; α-Glucosidase inhibitory activity.

MeSH terms

  • Acetophenones / isolation & purification
  • Acetophenones / pharmacology*
  • China
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Rutaceae / chemistry*

Substances

  • Acetophenones
  • Glycoside Hydrolase Inhibitors
  • Lignans
  • Phytochemicals