Thermovaccination - thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

Sergey D Varfolomeev; Alexander A Panin; Valeriy I Bykov; Svetlana B Tsybenova; Sergey V Zhuravel; Anna M Ryabokon; Irina I Utkina; Pavel V Gavrilov; Sergey S Petrikov; Lyudmila V Shogenova; Alexander G Chuchalin

doi:10.1016/j.cbi.2020.109339

Thermovaccination - thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

Chem Biol Interact. 2021 Jan 25:334:109339. doi: 10.1016/j.cbi.2020.109339. Epub 2020 Dec 11.

Affiliations

¹ Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
² LLC "MedTechInnovations", Blagoveshchenskii per, 3-1, 123001, Russia.
³ Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
⁴ Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia. Electronic address: s.tsybenova@gmail.com.
⁵ N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
⁶ Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia; Department of Chemistry, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia.
⁷ N.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russia.

Abstract

Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 °C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed.

Keywords: C-reactive protein; Coronavirus; Immunoglobulin G; Kinetic model; PCR-Test; Thermoheliox.

Publication types

Clinical Trial

MeSH terms

Administration, Inhalation
Adult
Aged
Antibodies, Viral / blood
C-Reactive Protein / biosynthesis
COVID-19 / immunology*
COVID-19 / therapy*
COVID-19 / virology
Helium / administration & dosage*
Hot Temperature
Humans
Hyperthermia, Induced / methods*
Immunoglobulin G / blood
Immunoglobulin M / blood
Kinetics
Middle Aged
Models, Immunological
Oxygen / administration & dosage*
SARS-CoV-2 / immunology
Vaccination / methods

Substances

Antibodies, Viral
Immunoglobulin G
Immunoglobulin M
Helium
C-Reactive Protein
Oxygen