Parvalbumin-containing GABAergic interneurons in the striatum, electrophysiologically identified as fast-spiking interneurons (FSIs), exert inhibitory control over striatal output to drive appropriate behavior. While a number of studies have emphasized their importance in motor control, it is unknown how these putative interneurons adapt their functional properties to different modes of movement selection. Here, we tested whether FSIs are sensitive to externally versus internally selected movements by recording their activity while two male rhesus monkeys performed reaching movements to visual targets. Two variants were used: an external condition, in which movements were instructed via external cues, and an internal condition, in which movements were guided by an internal representation of the target location. These conditions allowed to contrast the FSI activity associated with either externally cued or internally driven movement selection. After extensive training, reaching performance was only marginally affected by the type of movement, albeit with some differences between the monkeys. Over two-thirds of the FSIs were modulated around movement onset, regardless of the condition, and consisting mostly of increased activity. We found that a subset of FSIs showed stronger activation related to the initiation of movements in the external condition than in the internal condition, suggesting a dependence on movement selection mode. Moreover, this difference in the strength of FSI activation was predominant in the motor striatum. These data indicate that changes in FSI activity carry information that is scaled by constraints on action selection reflecting the involvement of local striatal inhibitory circuits in adaptation of behavior according to task demands.
Keywords: basal ganglia; microcircuits; movement initiation; nonhuman primate.
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.