Epidemiology of cutaneous and mucocutaneous leishmaniasis in Nicaragua

Santiago E Hernández-Bojorge; Gerardo G Blass-Alfaro; Marissa A Rickloff; Manuel J Gómez-Guerrero; Ricardo Izurieta

doi:10.1016/j.parepi.2020.e00192

Epidemiology of cutaneous and mucocutaneous leishmaniasis in Nicaragua

Parasite Epidemiol Control. 2020 Nov 26:11:e00192. doi: 10.1016/j.parepi.2020.e00192. eCollection 2020 Nov.

Authors

Santiago E Hernández-Bojorge^{1

2}, Gerardo G Blass-Alfaro², Marissa A Rickloff³, Manuel J Gómez-Guerrero², Ricardo Izurieta¹

Affiliations

¹ Global and Planetary Heal, College of Public Health, University of South Florida, Tampa, Florida, United States.
² Department of Microbiology and Parasitology, Faculty of Medical Sciences, Universidad Nacional Autónoma de Nicaragua-Managua, Nicaragua.
³ Department of Epidemiology, College of Public Health, University of South Florida, Tampa, Florida, United States.

Abstract

Leishmaniasis is a major neglected tropical disease which contributes a huge economic burden on already meager economic resources. The World Health Organization (WHO) has estimated an annual incidence of 700,000--1,000,000 patients and about 20,000-30,000 deaths per year. Approximately 66,941 patients of cutaneous leishmaniasis are reported annually in the Americas. In recent years, Nicaragua has presented alarmingly high numbers of patients and elevated incidence rates. Unfortunately, there are no detailed spatial descriptions on the epidemiological situation of leishmaniasis in this country. The objective of this study is to present descriptive data about the epidemiology of leishmaniasis in Nicaragua in the context of the distribution of this neglected tropical disease (NTD) in the Americas. This paper also provides an epidemiological update on different forms of leishmaniasis found in the three administrative regions of Nicaragua and its municipalities. Health authorities from the Ministry of Health of Nicaragua (MINSA) provided the entomological and epidemiological information for the different forms of the disease from 2001 to 2018. Prevalence, incidence rates, clinical classification of disease, age groups, sex, and geographic distribution by municipality and department are described in this study. Approximately 90%-95% of the national patients corresponded to CL and 5-10% correspond to MCL. The disease is distributed in the three regions of the country, with a higher burden in the Departments of Jinotega, Matagalpa and Atlántico Norte. The municipalities with the highest proportion of patients were El Cuá (23.92%), Waslala (14.16), Santa Maria de Pantasma (9.62%), Rancho Grande (9.03%) and Siuna (7.67%). There is an expansion of spatial distribution of CL and MCL in the North Central and South Atlantic regions of the country. These results could inform interventional strategies to address the burden of leishmaniasis in Nicaragua, which would improve the likelihood of meeting the goals for the Leishmaniasis Plan of Action for the Americas.

Keywords: Epidemiology; Leishmaniasis; Nicaragua; The Americas.