Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition

Antonela Del Giúdice; Lucas Pagura; María Celeste Capitani; Leandro Ernesto Mainetti; O Graciela Scharovsky; Ricardo José Di Masso; María José Rico; Viviana Rosa Rozados

doi:10.2144/fsoa-2019-0108

Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition

Future Sci OA. 2020 Oct 27;6(10):FSO589. doi: 10.2144/fsoa-2019-0108.

Authors

Antonela Del Giúdice^{1

2}, Lucas Pagura^{1

2}, María Celeste Capitani¹, Leandro Ernesto Mainetti^{1

2}, O Graciela Scharovsky^{1

2

3}, Ricardo José Di Masso^{1

3}, María José Rico^{1

2}, Viviana Rosa Rozados^{1

2}

Affiliations

¹ Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, Rosario 2000, Argentina.
² CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) CABA (C1425FQB), Argentina.
³ CIUNR (Consejo de Investigaciones, Universidad Nacional de Rosario) Rosario (2000), Argentina.

Abstract

Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting.

Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma.

Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response.

Keywords: cancer immunoediting; mammary adenocarcinoma; mathematical model.