Meta-Analysis of Randomized Controlled Trials of Xueshuantong Injection in Prevention of Deep Venous Thrombosis of Lower Extremity after Orthopedic Surgery

Shu-Ting Yan; Feng Gao; Tai-Wei Dong; Hao Fan; Miao-Miao Xi; Feng Miao; Pei-Feng Wei

doi:10.1155/2020/8877791

Meta-Analysis of Randomized Controlled Trials of Xueshuantong Injection in Prevention of Deep Venous Thrombosis of Lower Extremity after Orthopedic Surgery

Evid Based Complement Alternat Med. 2020 Nov 27:2020:8877791. doi: 10.1155/2020/8877791. eCollection 2020.

Authors

Shu-Ting Yan¹, Feng Gao¹, Tai-Wei Dong¹, Hao Fan¹, Miao-Miao Xi², Feng Miao², Pei-Feng Wei²

Affiliations

¹ College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Road, Qindu District, Xianyang, Shaanxi 712046, China.
² The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Weiyang West Road, Qindu District, Xianyang, Shaanxi 712046, China.

Abstract

Objective: To systematically evaluate the clinical efficacy of Xueshuantong injection (Panax notoginseng saponins) in preventing deep venous thrombosis (DVT) of lower extremity after orthopedic surgery.

Methods: The randomized controlled trials (RCTs) of Xueshuantong injection in prevention of lower extremity DVT after orthopedic surgery were retrieved from CNKI, Wanfang database, VIP, PubMed, and Cochrane Library by August 2020. Revman5.2 was used to analyze the results.

Results: A total of 20 articles including 2336 patients were included. The results of meta-analysis showed that the incidence of DVT in the experimental group was lower than that in the control group; after operation, the D-dimer (Ddimer), thrombin time (APTT), and prothrombin time (PT) in the experimental group were significantly improved compared with those in the control group, and the difference between the two groups was statistically significant.

Conclusion: Xueshuantong injection can effectively prevent the formation of lower extremity DVT after orthopedic surgery and antagonize the postoperative hypercoagulable state of blood, which has high clinical value.

Publication types

Review