The Prebiotic-Like Effects of Coprinus comatus Polysaccharides on Gut Microbiota in Normal Mice and Those with Acute Alcoholic Liver Injury: A Comparative Study

Weidong Li; Yongxia Wang; Min Sun; Yuting Liang; Xiaoqing Cai; Dongmei Qi; Yongqing Zhang; Chunchao Han

doi:10.1155/2020/2027570

The Prebiotic-Like Effects of Coprinus comatus Polysaccharides on Gut Microbiota in Normal Mice and Those with Acute Alcoholic Liver Injury: A Comparative Study

Evid Based Complement Alternat Med. 2020 Nov 28:2020:2027570. doi: 10.1155/2020/2027570. eCollection 2020.

Authors

Weidong Li¹, Yongxia Wang¹, Min Sun¹, Yuting Liang¹, Xiaoqing Cai¹, Dongmei Qi², Yongqing Zhang¹, Chunchao Han¹

Affiliations

¹ School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
² Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Abstract

This study aims to investigate the prebiotic-like effects of Coprinus comatus polysaccharides (CCP) on gut microbiota. Mice were divided into four groups: normal group (NG), alcohol group (AG), polysaccharides group (PG), and alcohol + polysaccharides group (APG). The gut microbiota structure of feces was analyzed by determining the V3-V4 region sequence in 16S rDNA. The results showed CCP could increase the diversity of gut microbiota. Compared with NG, PG had a significantly higher relative abundance of Firmicutes and Lactobacillaceae and a lower abundance of Rikenellaceae. These changes in gut microbiota result in positive effects on gut due to a series of prebiotic-like effects of CCP. At the same time, CCP could improve some adverse changes in gut microbiota caused by acute alcohol intake, such as the increased proportion of Firmicutes, Bacteroidetes, Muribaculaceae, and Lachnospiraceae and the decreased proportion of Rikenellaceae. In conclusion, the CCP has certain prebiotic effects not only on normal mice but also on mice with acute alcoholic liver injury.