The effect of sleep on the salivary cortisol response to acute stressors: a review and suggestions

Abstract

There have been steadily increasing studies on the relationship between sleep and stress. However, the findings regarding the effects of sleep on the acute stress response have been inconsistent. Elevated, blunted, or unchanged salivary cortisol stress response have been reported. Therefore, this study conducted a systematic review of previous studies to provide a comprehensive summary of the factors that influence the effects of sleep on the salivary cortisol stress response. We conducted a comprehensive electronic literature search in PubMed, PsycINFO, PsycARTICLES, Web of Science, MEDLINE, and EMBASE for human studies published in English (up to June 2019). Finally, 17 articles with participants aged 6.4-72 years were included in this review. We assessed the following factors: designing factors (sleep measurement, stress induction, cortisol sampling period, and time intervals between sleep measurement and the acute stress task), analyzing factors (cortisol analysis), and participants' characteristics (age, sex, and background stress levels); subsequently, we explained conflicting findings across the current literature. Further, we provide study design, analysis, and report suggestions for optimal assessment of the effects of sleep on the acute stress response. This summary of influencing factors and suggestions for future studies could help elucidate the impact of sleep on stress and advance the field.

Keywords: Acute stress; Influencing factors; Salivary cortisol; Sleep; Suggestions.