ANTs and cancer: Emerging pathogenesis, mechanisms, and perspectives

Lin Zhao; Min Tang; Ann M Bode; Weihua Liao; Ya Cao

doi:10.1016/j.bbcan.2020.188485

ANTs and cancer: Emerging pathogenesis, mechanisms, and perspectives

Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188485. doi: 10.1016/j.bbcan.2020.188485. Epub 2020 Dec 11.

Authors

Lin Zhao¹, Min Tang¹, Ann M Bode², Weihua Liao³, Ya Cao⁴

Affiliations

¹ Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha 410078, China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha 410078, China.
² The Hormel Institute, University of Minnesota, Austin, MN, USA.
³ Department of Radiology, Xiangya Hospital, Central South University, Changsha 410078, China.
⁴ Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha 410078, China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha 410078, China; Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, China; Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province, Changsha 410078, China; National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha 410078, China. Electronic address: ycao98@vip.sina.com.

PMID: 33309965
DOI: 10.1016/j.bbcan.2020.188485

Abstract

Adenine nucleotide translocases (ANTs) are a class of transporters located in the inner mitochondrial membrane that not only couple processes of cellular productivity and energy expenditure, but are also involved in the composition of the mitochondrial membrane permeability transition pore (mPTP). The function of ANTs has been found to be most closely related to their own conformational changes. Notably, as multifunctional proteins, ANTs play a key role in oncogenesis, which provides building blocks for tumor anabolism, control oxidative phosphorylation and glycolysis homeostasis, and govern cell death. Thus, ANTs constitute promising targets for the development of novel anticancer agents. Here, we review the recent findings regarding ANTs and their important mechanisms in cancer, with a focus on the therapeutic potential of targeting ANTs for cancer therapy.

Keywords: ADP/ATP transporter; ANTs; Carcinogenesis; Targeted therapy; mPTP.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinogenesis / genetics*
Carcinogenesis / metabolism
Cell Membrane Permeability / genetics
Cell Transformation, Neoplastic / genetics*
Cell Transformation, Neoplastic / metabolism
Energy Metabolism / genetics
Glycolysis / genetics
Humans
Mitochondria / genetics
Mitochondria / metabolism
Mitochondrial ADP, ATP Translocases / genetics*
Mitochondrial Permeability Transition Pore / metabolism
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology
Oxidative Phosphorylation

Substances

Mitochondrial Permeability Transition Pore
Mitochondrial ADP, ATP Translocases