[Thymoma and squamous thymic carcinoma diagnosis; experience from the RYTHMIC network]

Lara Chalabreysse; Romain Dubois; Véronique Hofman; Cécile Le Naoures; Audrey Mansuet-Lupo; Vincent Thomas de Montpréville; Anne De Muret; Marie Parrens; Nicolas Piton; Isabelle Rouquette; Véronique Secq; Cristina Singeorzan; Alexander Marx; Nicolas Girard; Benjamin Besse; Thierry Jo Molina

doi:10.1016/j.annpat.2020.11.002

[Thymoma and squamous thymic carcinoma diagnosis; experience from the RYTHMIC network]

Ann Pathol. 2021 Apr;41(2):154-165. doi: 10.1016/j.annpat.2020.11.002. Epub 2020 Dec 10.

[Article in French]

Authors

Lara Chalabreysse¹, Romain Dubois², Véronique Hofman³, Cécile Le Naoures⁴, Audrey Mansuet-Lupo⁵, Vincent Thomas de Montpréville⁶, Anne De Muret⁷, Marie Parrens⁸, Nicolas Piton⁹, Isabelle Rouquette¹⁰, Véronique Secq¹¹, Cristina Singeorzan¹², Alexander Marx¹³, Nicolas Girard¹⁴, Benjamin Besse¹⁵, Thierry Jo Molina¹⁶

Affiliations

¹ Département de pathologie, groupement hospitalier est, hospices civils de Lyon, Lyon, France.
² Institut de pathologie, CHU de Lille, Lille, France.
³ Laboratoire de pathologie clinique et expérimentale, FHU OncoAge, Biobank 0033-00025, université Côte d'Azur, hôpital Pasteur, Nice, France.
⁴ Département de pathologie, CHU de Rennes, Rennes, France.
⁵ Inserm U1138, centre de recherche des Cordeliers, département de pathologie, université de Paris, hôpital universitaire Cochin, AP-HP centre, Paris, France.
⁶ Département de pathologie, hôpital Marie-Lannelongue, Le plessis-Robinson, France.
⁷ Service d'anatomie pathologique, CHU de Tours, Tours, France.
⁸ Inserm U1053, service d'anatomie pathologique, CHU de Bordeaux, université de Bordeaux, Bordeaux, France.
⁹ Inserm U1245, service de pathologie, CHU de Rouen, Rouen, France.
¹⁰ Laboratoire d'anatomie pathologique, CHU de Toulouse oncopole, Toulouse, France.
¹¹ Département de pathologie, AP-HM Marseille, Marseille, France.
¹² Service d'anatomie pathologique, CHU de Besançon, Besançon, France.
¹³ Institut de pathologie, université médicale de Mannheim, université de Heidelberg, Mannheim, Allemagne.
¹⁴ Institut du thorax Curie Montsouris, institut Curie, Paris, France.
¹⁵ Département de médecine oncologique, institut Gustave-Roussy, Villejuif, France; Paris-Sud-université, Orsay, France.
¹⁶ Inserm U1163, service d'anatomie pathologique, institut imagine, université de Paris, hôpital universitaire Necker-Enfants malades, AP-HP centre, 149, rue de Sèvres, 75015 Paris, France. Electronic address: thierry.molina@%20aphp.fr.

PMID: 33309329
DOI: 10.1016/j.annpat.2020.11.002

Abstract

The RYTHMIC network, supported by the French National Cancer Institute is dedicated to the management of patients with thymic epithelial tumors through regional and national multidisciplinary tumor boards. Tumor board decisions are based on the initial pathology diagnoses. However, following clinical inclusion in the network, a central pathology review is organized, implicating a panel of pathologists, for histotype and stage classification, which is different from a classical second opinion from pathologist to pathologist for a difficult case. Thanks to the participation of all French pathologists, more than 1000 cases have been reviewed by the panel. The aim of this review is to share with the French pathology community, the experience of the group. It underlines the importance of macroscopy and surgeon-pathologist involvement to allow a good central review, the main histopathological and immunophenotypical patterns of the most frequent thymomas and thymic carcinoma types, the differential diagnoses, as well as the difficulties for the panel to reproducibly assess on slides, stage, for some cases.

Keywords: Carcinome thymique; Immunohistochemistry; Immunohistochimie; RYTHMIC; Stade; Stage; Thymic carcinoma; Thymoma; Thymome.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell* / diagnosis
Diagnosis, Differential
Humans
Neoplasms, Glandular and Epithelial*
Thymoma* / diagnosis
Thymus Neoplasms* / diagnosis