Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia in a Newborn Treated With Remdesivir and Coronavirus Disease 2019 Convalescent Plasma

Andrew J Hopwood; Alejandro Jordan-Villegas; Liliana D Gutierrez; Mallory C Cowart; Wilfredo Vega-Montalvo; Wang Leung Cheung; Michael J McMahan; Michael R Gomez; Federico R Laham

doi:10.1093/jpids/piaa165

Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia in a Newborn Treated With Remdesivir and Coronavirus Disease 2019 Convalescent Plasma

J Pediatric Infect Dis Soc. 2021 May 28;10(5):691-694. doi: 10.1093/jpids/piaa165.

Authors

Andrew J Hopwood¹, Alejandro Jordan-Villegas², Liliana D Gutierrez², Mallory C Cowart³, Wilfredo Vega-Montalvo⁴, Wang Leung Cheung⁵, Michael J McMahan⁶, Michael R Gomez⁶, Federico R Laham²

Affiliations

¹ Department of Pediatrics, Arnold Palmer Hospital for Children, Orlando Health, Orlando, Florida, USA.
² Pediatric Infectious Diseases, Arnold Palmer Hospital for Children, Orlando Health, Orlando, Florida, USA.
³ Department of Pharmacy, Arnold Palmer Hospital for Children, Orlando Health, Orlando, Florida, USA.
⁴ Department of Obstetrics and Gynecology, Winnie Palmer Hospital for Women & Babies, Orlando Health, Orlando, Florida, USA.
⁵ Department of Pathology, Orlando Regional Medical Center, Orlando Health, Orlando, Florida, USA.
⁶ Alexander Center of Neonatology, Winnie Palmer Hospital for Women & Babies, Orlando Health, Orlando, Florida, USA.

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel pandemic virus. Mounting evidence supports the possibility of vertical transmission, which at the present time appears to be rare. We report a newborn with vertically acquired SARS-CoV-2 who developed acute respiratory failure and received remdesivir and coronavirus disease 2019 convalescent plasma.

Keywords: COVID-19; SARS-CoV-2; coronavirus; newborn; remdesivir; treatment; vertical transmission.

© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Publication types

Case Reports

MeSH terms

Adenosine Monophosphate / analogs & derivatives*
Adenosine Monophosphate / therapeutic use
Adolescent
Alanine / analogs & derivatives*
Alanine / therapeutic use
Antiviral Agents / therapeutic use*
COVID-19 / therapy*
COVID-19 / transmission*
COVID-19 Serotherapy
Female
Humans
Immunization, Passive
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pneumonia, Viral / therapy*
Pneumonia, Viral / transmission*
Pneumonia, Viral / virology
SARS-CoV-2

Substances

Antiviral Agents
remdesivir
Adenosine Monophosphate
Alanine