Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: Challenges and opportunities

Majid Sharifi; Anwarul Hasan; Setareh Haghighat; Akbar Taghizadeh; Farnoosh Attar; Samir Haj Bloukh; Zehra Edis; Mengzhou Xue; Suliman Khan; Mojtaba Falahati

doi:10.1016/j.talanta.2020.121704

Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: Challenges and opportunities

Talanta. 2021 Feb 1;223(Pt 1):121704. doi: 10.1016/j.talanta.2020.121704. Epub 2020 Sep 28.

Authors

Affiliations

¹ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
² Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Center, Qatar University, Doha 2713, Qatar.
³ Department of Microbiology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
⁴ Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
⁵ Department of Food Toxicology, Research Center of Food Technology and Agricultural Products, Standard Research Institute (SRI), Karaj, Iran.
⁶ Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, PO Box 346, Ajman, United Arab Emirates.
⁷ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, PO Box 346, Ajman, United Arab Emirates.
⁸ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
⁹ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: Suliman.khan18@gmail.com.
¹⁰ Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: mojtaba.falahati@alumni.ut.ac.ir.

Abstract

The rapid outbreak of coronavirus disease 2019 (COVID-19) around the world is a tragic and shocking event that demonstrates the unpreparedness of humans to develop quick diagnostic platforms for novel infectious diseases. In fact, statistical reports of diagnostic tools show that their accuracy, specificity and sensitivity in the detection of COVID hampered by some challenges that can be eliminated by using nanoparticles (NPs). In this study, we aimed to present an overview on the most important ways to diagnose different kinds of viruses followed by the introduction of nanobiosensors. Afterward, some methods of COVID-19 detection such as imaging, laboratory and kit-based diagnostic tests are surveyed. Furthermore, nucleic acids/protein- and immunoglobulin (Ig)-based nanobiosensors for the COVID-19 detection infection are reviewed. Finally, current challenges and future perspective for the development of diagnostic or monitoring technologies in the control of COVID-19 are discussed to persuade the scientists in advancing their technologies beyond imagination. In conclusion, it can be deduced that as rapid COVID-19 detection infection can play a vital role in disease control and treatment, this review may be of great help for controlling the COVID-19 outbreak by providing some necessary information for the development of portable, accurate, selectable and simple nanobiosensors.

Keywords: COVID-19; Coronavirus; Diagnostics; Global health; Nanobiosensors.

Publication types

Review

MeSH terms

Biosensing Techniques*
COVID-19 / diagnosis*
Humans
Nanotechnology*
Reagent Kits, Diagnostic
Sensitivity and Specificity

Substances

Reagent Kits, Diagnostic