Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial

J Pediatr. 2021 Apr:231:273-277.e3. doi: 10.1016/j.jpeds.2020.12.001. Epub 2020 Dec 8.

Abstract

This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire. Trial registration Clinicaltrials.gov: NCT01490580.

Keywords: ages and stages questionnaire; anesthesia; neurodevelopment; neurotoxicity; newborn; pain.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Anesthesia / administration & dosage*
  • Anesthetics, Combined / administration & dosage*
  • Atracurium / administration & dosage*
  • Atropine / administration & dosage*
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Intubation, Intratracheal*
  • Male
  • Nervous System / growth & development*
  • Propofol / administration & dosage*
  • Sufentanil / administration & dosage*
  • Time Factors
  • Treatment Outcome

Substances

  • Adjuvants, Anesthesia
  • Anesthetics, Combined
  • Atracurium
  • Atropine
  • Sufentanil
  • Propofol

Associated data

  • ClinicalTrials.gov/NCT01490580